All Publications

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Mechanical stress regulates insulin sensitivity through integrin-dependent control of insulin receptor localization
Kim J, Bilder D* and T Neufeld* (*co-corresponding authors)
Genes & Development, 2018, Feb 32: 156-164.

 

 

 

 

 

 

A Cell Migration Tracking Tool Supports Coupling of Tissue Rotation to Elongation.
Dong-Yuan Chen, Justin Crest, David Bilder
Cell Reports. 2017 October 17;21(3):559-569.

 

 

 

 

 

 

Taking stock of the Drosophila research ecosystem.

David Bilder and Ken Irvine.

Genetics, 2017 July 206(3): 1227-1236.

 

 

 

 

 

Organ sculpting by patterned extracellular matrix stiffness.

Crest J, Diz-Muñoz A, Chen DY, Fletcher DA, Bilder D

Elife. 2017 Jun 27;6. pii: e24958. doi: 10.7554/eLife.24958

 

 

 

‘

 

 

Microenvironmental autophagy promotes tumour growth.

Katheder N, O´Farrell F, Khezri R, Schultz SW, Jain A, Johansen T, Juhasz G, Bilder D, Brech A, Stenmark H and Rusten TE

Nature. 2017 Jan 19;541(7637):417-420.

 

 

 

 

Symmetry Breaking in an Edgeless Epithelium by Fat2-Regulated Microtubule Polarity.
Dong-Yuan Chen, Katherine R. Lipari, Yalda Dehghan, Sebastian J. Streichan, David Bilder (2016).
Cell Reports, May 10;15(6):1125-33.

 

 

 

 

 

Malignant Drosophila tumors interrupt insulin signaling to induce cachexia-like wasting.
Figueroa-Clarevega A and D Bilder (2015).
Dev Cell 33, 47-55.

 

 

 

The Transcriptional Response to Tumorigenic Polarity Loss in Drosophila.
Bunker BD, Nellimoottil TT, Boileau R, Classen AK, and D Bilder (2015).
eLife, Feb 26;4. doi: 10.7554/eLife.03189.

 

 

The F-box protein Slmb restricts the activity of aPKC to polarize epithelial cells.
Skwarek LC, Windler SL, de Vreede G, Rogers GC, Bilder D.
Development, 2014 Aug;141(15):2978-83

 

 

The Scribble module regulates retromer-dependent endocytic trafficking during epithelial polarization.
de Vreede G, Schoenfeld JD, Windler SL, Morrison H, Lu H, Bilder D.
Development, 2014 Jul;141(14):2796-802

 

 

SCFSlimb ubiquitin ligase suppresses condensin II-mediated nuclear reorganization by degrading Cap-H2.
Buster DW, Daniel SG, Nguyen HQ, Windler SL, Skwarek LC, Peterson M, Roberts M, Meserve JH, Hartl T, Klebba JE, Bilder D, Bosco G, Rogers GC.
J Cell Biol. 2013 Apr 1;201(1):49-63. doi: 10.1083/jcb.201207183. Epub 2013 Mar 25.

 

A screen for round egg mutants in Drosophila identifies tricornered, furry, and misshapen as regulators of egg chamber elongation.
Horne-Badovinac S, Hill J, Gerlach G 2nd, Menegas W, Bilder D.
G3 (Bethesda), 2012 Mar;2(3):371-8

 

Expanding the morphogenetic repertoire: perspectives from the Drosophila egg.
Bilder D, Haigo SL.
Dev Cell, 2012 Jan 17;22(1):12-23

 

 

Altered modes of stem cell division drive adaptive intestinal growth.
O’Brien LE, Soliman SS, Li X, Bilder D.
Cell, 2011 Oct 28;147(3):603-14.

 

 

Global Tissue Revolutions in a Morphogenetic Movement Controlling Elongation.
Haigo SL, Bilder D.
Science, 2011,Feb 25:331(6020):1071-4

 

 

The functions of auxilin and Rab11 in Drosophila suggest that the fundamental role of ligand endocytosis in notch signaling cells is not recycling.
Banks SM, Cho B, Eun SH, Lee JH, Windler SL, Xie X, Bilder D, Fischer JA.
PLoS One. 2011 Mar 23;6(3):e18259. doi: 10.1371/journal.pone.0018259.

a

Endocytic internalization routes required for Delta/Notch signaling.
Windler S, Bilder D.
Current Biology, 2010, Mar 23;20(6):538-43.

 

 

 

The vacuolar ATPase is required for physiological as well as pathological Notch signaling activation.
Vaccari T, Bilder D.
Development, 2010, Jun: 137 (11): 1825-32

 

 

 

Polarity and endocytosis; reciprocal regulation.
Shivas JM, Morrison HA, Bilder D, Skop A.
Trends in Cell Biology, 2010, Aug: 20(8): 445-52.

 

 

 

A tumor suppressive activity of Drosophila Polycomb genes mediated by JAK/STAT signaling.
Classen AK, Bunker BD, Harvey KF, Vaccari T, Bilder D.
Nature Genetics, 2009, Oct;41(10):1150-5.

 

 

 

Endocytic regulation of Notch signaling.
Fortini ME, Bilder D.
Current Opinion in Genetics and Development, 2009 Aug;19(4):323-8.

 

 

 

Quantitative analysis of epithelial morphogenesis in Drosophila oogenesis: New insights based on morphometric analysis and mechanical modeling.
Kolahi KS, White PF, Shreter DM, Classen AK, Bilder D, Mofrad MR.
Dev Biol. 2009 Jul 15;331(2):129-39. doi: 10.1016/j.ydbio.2009.04.028. Epub 2009 May 3.

 

 

 

Comparative analysis of ESCRT-I, ESCRT-II and ESCRT-III function in Drosophila by efficient isolation of ESCRT mutants.
Vaccari T, Rusten TE, Menut L, Nezis IP, Brech A, Stenmark H, Bilder D.
Journal of Cell Science, 2009 Jul 15;122(Pt 14):2413-23

 

 

 

At the crossroads of polarity, proliferation and apoptosis: the use of Drosophila to unravel the multifaceted role of endocytosis in tumor suppression.
Vaccari T, Bilder D.
Mol Oncol. 2009 Aug;3(4):354-65. doi: 10.1016/j.molonc.2009.05.005. Epub 2009 Jun 6. Review.

 

Regulation of early endosomal entry by the Drosophila tumor suppressors Rabenosyn and Vps45.
Morrison HA, Dionne H, Rusten TE, Brech A, Fisher WW, Pfeiffer BD, Celniker SE, Stenmark H, Bilder D.
Molecular Biology of the Cell, 2008 Oct;19(10):4167-76.

 

 

 

Endosomal entry regulates Notch receptor activation in Drosophila melanogaster.
Vaccari T, Lu H, Kanwar R, Fortini ME, Bilder D.
Journal of Cell Biology, 2008 Feb 25;180(4):755-62.

 

Dynein regulates epithelial polarity and the apical localization of stardust A mRNA.
Horne-Badovinac S, Bilder D.
PLoS Genetics, 2008 Jan;4(1):e8.

 

A mosaic genetic screen for Drosophila neoplastic tumor suppressor genes based on defective pupation.
Menut L, Vaccari T, Dionne H, Hill J, Wu G, Bilder D.
Genetics, 2007 Nov;177(3):1667-77.

 

Regulation of imaginal disc growth by tumor-suppressor genes in Drosophila.
Hariharan IK, Bilder D.
Annual Review of Genetics, 2006 Vol. 40:335-61.

 

 

 

 

Endocytic control of epithelial polarity and proliferation in Drosophila.
Lu H, Bilder D.
Nature Cell Biology, 2005 Oct; 232(3):559-74.

 

 

 

 

The Drosophila Tumor Suppressor vps25 Prevents Nonautonomous Overproliferation by Regulating Notch Trafficking.
Vaccari T, Bilder D.
Developmental Cell,2005 Nov; 9(5):687-98.

 

 

 

 

 

Mass transit: epithelial morphogenesis in the Drosophila egg chamber.
Horne-Badovinac S, Bilder D.
Developmental Dynamics, 2005 Mar; 232(3):559-74.

 

 

Domains controlling cell polarity and proliferation in the Drosophila tumor suppressor Scribble. Zeitler J, Hsu CP, Dionne H, Bilder D. Journal of Cell Biology,2004 Dec 20;167(6):1137-46.

 

 

 

Epithelial polarity and proliferation control: links from the Drosophila neoplastic tumor suppressors.
Bilder D
Genes and Development, 2004 Aug 15;18(16):1909-25.

 

Integrated activity of PDZ protein complexes mediates the maturation of epithelial polarity.
Bilder D, Schober M, Perrimon N.
Nature Cell Biology, 2003 Jan; 5(1):53-8.

a

a

 

 

Polarity determination in breast tissue: desmosomal adhesion, myoepithelial cells, and laminin 1.
Bissell MJ, Bilder D.
Breast Cancer Research, 2003 5(2):117-9.

 

 

 

 

Neurotic, a novel maternal neurogenic gene, encodes an O-fucosyltransferase that is essential for Notch-Delta interactions.

Sasamura T, Sasaki N, Miyashita F, Nakao S, Ishikawa HO, Ito M, Kitagawa M, Harigaya K, Spana E, Bilder D, Perrimon N, Matsuno K.

Development. 2003 Oct;130(20):4785-95. Epub 2003 Aug 13.

 

 

Mechanism of inhibition of the Drosophila and mammalian EGF receptors by the transmembrane protein Kekkon 1.
Ghiglione C, Amundadottir L, Andresdottir M, Bilder D, Diamonti JA, Noselli S, Perrimon N, Carraway III KL.
Development. 2003 Sep;130(18):4483-93.

a

 

a

 

Recruitment of Scribble to the synaptic scaffolding complex requires GUK-holder, a novel DLG binding protein. Mathew D, Gramates LS, Packard M, Thomas U, Bilder D, Perrimon N, Gorczyca M, Budnik V.
Current Biology, 2002 12 :531-9.

 

 

 

 

PDZ proteins and polarity: functions from the fly.
Bilder D.
Trends in Genetics, 2001 17 : 511-8.

 

 

 

Cell polarity: squaring the circle.
Bilder D.
Current Biology, 2001 11 (4):R132-5.

 

 

 

Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors.
Bilder D, Li M, Perrimon N.

Science, 2000 289 (5476): 113-6.

 

Collective nomenclature for LAP proteins. Bilder D, Birnbaum D, Borg JP, Bryant P, Huigbretse J, Jansen E, Kennedy MB, Labouesse M, Legouis R, Mechler B, Perrimon N, Petit M, Sinha P.
Nature Cell Biology, 2000 2(7): E114.

 

 

 

 

Localization of apical epithelial determinants by the basolateral PDZ protein Scribble.
Bilder D, Perrimon N.
Nature, 2000 403 (6770): 676-80.
cf comment in Nature 403:611-2.